Enables S-adenosyl-L-methionine binding activity and protein methyltransferase activity. Involved in several processes, including positive regulation of protein localization to nucleus; regulation of dauer entry; and response to stress. Located in cytoplasm. Expressed in head; intestinal cell; pharyngeal cell; ventral nerve cord; and vulval cell. Is an ortholog of human PRMT8 (protein arginine methyltransferase 8).
Predicted to enable phosphatidylinositol 3-kinase regulator activity and protein-membrane adaptor activity. Involved in macroautophagy; positive regulation of autophagy; and positive regulation of embryonic development. Located in cytoplasm. Expressed in neurons and pharyngeal muscle cell.
Enables protein kinase binding activity. Involved in aggrephagy. Predicted to be located in phagophore assembly site. Predicted to be part of Atg1/ULK1 kinase complex. Expressed in several structures, including body wall musculature; head; hypodermis; pharyngeal muscle cell; and tail. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; and hepatocellular carcinoma. Is an ortholog of human ATG101 (autophagy related 101).
Enables phosphatidylinositol phosphate binding activity. Involved in autophagosome assembly. Located in cytoplasm. Expressed widely. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Is an ortholog of human WDR45 (WD repeat domain 45).
Predicted to be involved in signal transduction. Is an ortholog of human TCP11 (t-complex 11); TCP11L1 (t-complex 11 like 1); and TCP11L2 (t-complex 11 like 2).
Enables ubiquitin-protein transferase activity. Involved in anaphase-promoting complex-dependent catabolic process; embryo development; and meiotic chromosome segregation. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Expressed in germ line. Is an ortholog of human ANAPC11 (anaphase promoting complex subunit 11).