Enables thymidylate synthase activity. Involved in dTMP biosynthetic process. Predicted to be located in cytosol and mitochondrion. Expressed in body wall musculature; gonad; nerve ring; and terminal bulb. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human TYMS (thymidylate synthetase).
Is affected by several genes including nuo-6; isp-1; and emb-4 based on RNA-seq and microarray studies. Is affected by cadmium; Sirolimus; and allantoin based on microarray studies.