Enables sequence-specific DNA binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Expressed in vulval precursor cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Lewy body dementia; and schizophrenia. Is an ortholog of human ELK1 (ETS transcription factor ELK1).
Enables PDZ domain binding activity. Involved in protein localization and regulation of protein deneddylation. Located in basement membrane and presynaptic active zone. Expressed in nervous system. Is an ortholog of human ERC2 (ELKS/RAB6-interacting/CAST family member 2).
Enables GTPase activator activity; Roundabout binding activity; and small GTPase binding activity. Involved in several processes, including axo-dendritic transport; cell projection organization; and locomotion. Located in presynaptic membrane. Expressed in nerve ring and neurons. Is an ortholog of human SYDE2 (synapse defective Rho GTPase homolog 2).