- ego-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA-dependent RNA polymerase activity. Involved in gamete generation; nuclear pore localization; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in P granule; condensed nuclear chromosome; and metaphase plate. Expressed in germ line.
- ego-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in positive regulation of Notch signaling pathway and protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Expressed widely. Is an ortholog of human PTPN23 (protein tyrosine phosphatase non-receptor type 23).
- alx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables Notch binding activity. Involved in several processes, including endocytic recycling; endosome organization; and regulation of protein catabolic process. Located in basolateral plasma membrane; multivesicular body; and recycling endosome. Expressed in several structures, including vulva. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human PDCD6IP (programmed cell death 6 interacting protein).
- rrf-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA-dependent RNA polymerase activity. Involved in regulatory ncRNA-mediated heterochromatin formation and spermatogenesis. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Expressed in head and tail.
- nphp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including determination of adult lifespan; male mating behavior; and plasma membrane bounded cell projection organization. Located in ciliary basal body; ciliary transition zone; and non-motile cilium. Expressed in cloacal ganglion; neurons; and tail ganglion. Used to study Meckel syndrome and nephronophthisis. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 4; Senior-Loken syndrome; and nephronophthisis 4. Is an ortholog of human NPHP4 (nephrocystin 4).