Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of centrosome duplication; and regulation of vulval development. Located in axon and cytoplasm. Expressed in body wall musculature; gonad; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Is an ortholog of human FBXW7 (F-box and WD repeat domain containing 7).
Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2).
Is affected by several genes including prg-1; hrpk-1; and alg-1 based on RNA-seq studies. Is affected by four chemicals including methylmercury hydroxide; multi-walled carbon nanotube; and nicotine based on RNA-seq studies.
Enables mRNA binding activity and translation repressor activity. Involved in several processes, including negative regulation of gene expression; nematode male tail tip morphogenesis; and regulation of developmental process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and ribonucleoprotein granule. Expressed in several structures, including germ cell; hypodermal cell; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human TRIM71 (tripartite motif containing 71).
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in body wall musculature; neurons; and somatic nervous system.
Enables store-operated calcium channel activity. Involved in calcium ion transport; intracellular calcium ion homeostasis; and single fertilization. Located in cytoplasmic vesicle and pseudopodium membrane. Expressed in sperm and spermatid.
Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and egg-laying behavior. Predicted to be located in axon; membrane; and somatodendritic compartment. Expressed in HSNL; HSNR; PVQL; PVQR; and vulva.