che-10

Caenorhabditis elegans

Involved in cilium assembly. Located in ciliary basal body and ciliary transition zone. Is an ortholog of human CEP250 (centrosomal protein 250) and CROCC (ciliary rootlet coiled-coil, rootletin).

dyf-3

Caenorhabditis elegans

Involved in several processes, including chemosensory behavior; cilium assembly; and response to alkaline pH. Located in axon; dendrite; and neuronal cell body. Expressed in neurons. Is an ortholog of human CLUAP1 (clusterin associated protein 1).

dyf-19

Caenorhabditis elegans

Involved in non-motile cilium assembly. Located in ciliary basal body and dendrite. Expressed in ciliated neurons. Is an ortholog of human FBF1 (Fas binding factor 1).

dyf-10

Caenorhabditis elegans

dyf-12

Caenorhabditis elegans

dyf-5

Caenorhabditis elegans

Enables protein serine/threonine kinase activity. Involved in cilium organization; protein localization; and regulation of non-motile cilium assembly. Located in neuronal cell body and plasma membrane bounded cell projection. Expressed in lateral ganglion and neurons. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome; juvenile myoclonic epilepsy 10; and retinitis pigmentosa 62. Is an ortholog of human MAK (male germ cell associated kinase).

dyf-7

Caenorhabditis elegans

Involved in amphid sensory organ dendrite retrograde extension and neuron projection extension. Located in dendrite membrane.

dyf-6

Caenorhabditis elegans

Involved in intraciliary transport and non-motile cilium assembly. Located in dendrite and neuronal cell body. Expressed in ciliated neurons and hypodermis. Is an ortholog of human IFT46 (intraflagellar transport 46).

dyf-2

Caenorhabditis elegans

Involved in several processes, including chemotaxis; cilium organization; and olfactory behavior. Acts upstream of or within cilium assembly and intraciliary retrograde transport. Located in non-motile cilium. Part of intraciliary transport particle B. Expressed in neurons and oxygen sensory neurons. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; and asphyxiating thoracic dystrophy 5. Is an ortholog of human WDR19 (WD repeat domain 19).

dyf-11

Caenorhabditis elegans

Predicted to enable microtubule binding activity. Involved in several processes, including cilium organization; dauer entry; and hyperosmotic response. Located in axoneme and ciliary basal body. Part of intraciliary transport particle B. Expressed in ciliated neurons and sensory neurons. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Is an ortholog of human TRAF3IP1 (TRAF3 interacting protein 1).