Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Is an ortholog of human SMC4 (structural maintenance of chromosomes 4).
Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like).
Involved in dosage compensation by hypoactivation of X chromosome; meiotic sister chromatid segregation; and mitotic sister chromatid segregation. Located in condensed nuclear chromosome. Part of dosage compensation complex. Expressed widely.
Predicted to enable histone binding activity. Involved in meiotic sister chromatid segregation; mitotic sister chromatid segregation; and negative regulation of reciprocal meiotic recombination. Located in X chromosome and nucleus. Part of dosage compensation complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human NCAPD2 (non-SMC condensin I complex subunit D2).
Is affected by several genes including etr-1; dpy-7; and cnd-1 based on RNA-seq studies. Is affected by six chemicals including Sodium Chloride; Psoralens; and allantoin based on RNA-seq studies.
A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Located in annular furrow extracellular matrix. Expressed in several structures, including P1; P12; P2; cuticle; and hypodermis. Used to study skin disease.
Is affected by several genes including drh-3; dpy-21; and mog-7 based on RNA-seq studies. Is affected by five chemicals including aldicarb; rifampin; and Psoralens based on microarray and RNA-seq studies.
Is affected by several genes including dpy-7; smn-1; and clk-1 based on microarray and RNA-seq studies. Is affected by four chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies.
A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in hypodermis.