Involved in dosage compensation by hypoactivation of X chromosome; meiotic sister chromatid segregation; and mitotic sister chromatid segregation. Located in condensed nuclear chromosome. Part of dosage compensation complex. Expressed widely.
Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Is an ortholog of human SMC4 (structural maintenance of chromosomes 4).
Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like).
Enriched in intestine based on single-cell RNA-seq studies. Is affected by several genes including mrps-5; dpy-21; and hlh-26 based on RNA-seq and microarray studies.
Predicted to enable histone binding activity. Involved in meiotic sister chromatid segregation; mitotic sister chromatid segregation; and negative regulation of reciprocal meiotic recombination. Located in X chromosome and nucleus. Part of dosage compensation complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human NCAPD2 (non-SMC condensin I complex subunit D2).
Enriched in ASHL and germ line based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including etr-1; dpy-21; and hlh-26 based on RNA-seq and microarray studies. Is affected by Doxorubicin based on RNA-seq studies.