Involved in dosage compensation by hypoactivation of X chromosome; meiotic sister chromatid segregation; and mitotic sister chromatid segregation. Located in condensed nuclear chromosome. Part of condensin complex and dosage compensation complex. Expressed widely.
Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Is an ortholog of human SMC4 (structural maintenance of chromosomes 4).
Predicted to enable histone binding activity. Involved in meiotic sister chromatid segregation; mitotic sister chromatid segregation; and negative regulation of reciprocal meiotic recombination. Located in X chromosome and nucleus. Part of condensin complex and dosage compensation complex. Is an ortholog of human NCAPD2 (non-SMC condensin I complex subunit D2).
Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like).
Is affected by several genes including hsf-1; dpy-26; and sdc-3 based on RNA-seq and microarray studies. Is affected by Sirolimus based on microarray studies.
Is affected by several genes including dpy-26; sir-2.1; and ogt-1 based on RNA-seq and microarray studies. Is affected by cadmium and Sirolimus based on microarray studies.
Is affected by several genes including grd-1; npr-15; and dpy-26 based on RNA-seq studies. Is affected by four chemicals including atracurium; bortezomib; and Tamoxifen based on RNA-seq studies.