dop-3

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; male mating behavior; and response to odorant. Predicted to be located in plasma membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; drug dependence (multiple); and end stage renal disease. Is an ortholog of human DRD3 (dopamine receptor D3).

Y19D10A.10

Caenorhabditis elegans

Enriched in DA neuron; I5 neuron; SAB; VA neuron; and retrovesicular ganglion based on microarray studies. Is affected by several genes including rsr-2; rrf-3; and dop-1 based on tiling array; RNA-seq; and microarray studies. Is affected by six chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.

dop-6

Caenorhabditis elegans

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cellular response to dopamine; and chemical synaptic transmission. Predicted to be located in dendrite and plasma membrane. Expressed in several structures, including AVF; SMDVL; head neurons; intestine; and lumbar neurons.

dop-1

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gs; epinephrine binding activity; and norepinephrine binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; habituation; and mechanosensory behavior. Predicted to be located in dendrite and plasma membrane. Expressed in several structures, including accessory cell; excretory gland cell; head muscle; mechanosensory neurons; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; attention deficit hyperactivity disorder; blepharospasm; and kidney failure. Is an ortholog of human DRD1 (dopamine receptor D1).

dop-5

Caenorhabditis elegans

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in dendrite and plasma membrane. Expressed in neurons.

srg-18

Caenorhabditis elegans

Enriched in DA neuron; I5 neuron; SAB; VA neuron; and retrovesicular ganglion based on microarray studies. Is affected by several genes including rrf-3; clk-1; and sir-2.1 based on microarray and RNA-seq studies.

F11D5.6

Caenorhabditis elegans

Enriched in DA neuron; VA neuron; body wall muscle cell; and hypodermis based on tiling array studies. Is affected by several genes including rsr-2; lpd-3; and smg-2 based on tiling array; RNA-seq; and microarray studies.

max-5

Caenorhabditis elegans

F56A4.11

Caenorhabditis elegans

Is affected by several genes including dop-1; glh-4; and glh-1 based on microarray and RNA-seq studies. Is affected by lithium chloride based on microarray studies.

Y46D2A.3

Caenorhabditis elegans

Enriched in DA neuron; DA9; and PDA based on single-cell RNA-seq studies. Is affected by several genes including drh-3; hpl-2; and tph-1 based on tiling array and RNA-seq studies. Is affected by rifampin; allantoin; and Sirolimus based on RNA-seq and microarray studies.