dop-3

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; male mating behavior; and response to odorant. Predicted to be located in plasma membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; drug dependence (multiple); and end stage renal disease. Is an ortholog of human DRD3 (dopamine receptor D3).

dop-6

Caenorhabditis elegans

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cellular response to dopamine; and chemical synaptic transmission. Predicted to be located in dendrite and plasma membrane. Expressed in several structures, including AVF; SMDVL; head neurons; intestine; and lumbar neurons.

dop-5

Caenorhabditis elegans

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in dendrite and plasma membrane. Expressed in neurons.

dop-1

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gs; epinephrine binding activity; and norepinephrine binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; habituation; and mechanosensory behavior. Predicted to be located in dendrite and plasma membrane. Expressed in several structures, including accessory cell; excretory gland cell; head muscle; mechanosensory neurons; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; attention deficit hyperactivity disorder; blepharospasm; and kidney failure. Is an ortholog of human DRD1 (dopamine receptor D1).

F56A4.11

Caenorhabditis elegans

Is affected by several genes including dop-1; glh-4; and glh-1 based on microarray and RNA-seq studies. Is affected by lithium chloride based on microarray studies.

Y19D10A.10

Caenorhabditis elegans

Enriched in DA neuron; I5 neuron; SAB; VA neuron; and retrovesicular ganglion based on microarray studies. Is affected by several genes including rsr-2; rrf-3; and dop-1 based on tiling array; RNA-seq; and microarray studies. Is affected by six chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.

str-267

Caenorhabditis elegans

Enriched in AVK based on RNA-seq and microarray studies. Is affected by several genes including mut-2; dpl-1; and dop-1 based on microarray and RNA-seq studies. Is affected by nine chemicals including mianserin; metformin; and Sirolimus based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: 7TM GPCR, serpentine receptor class r (Str) and Serpentine type 7TM GPCR chemoreceptor Str.

elk-2

Caenorhabditis elegans

Enriched in OLL; PVD; and head mesodermal cell based on microarray and RNA-seq studies. Is affected by several genes including etr-1; dop-1; and unc-30 based on microarray and RNA-seq studies. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Lewy body dementia; and schizophrenia. Is an ortholog of human ELK1 (ETS transcription factor ELK1). Human ELK1 enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor coactivator activity.

dop-2

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including cellular response to organonitrogen compound; male mating behavior; and regulation of locomotion involved in locomotory behavior. Predicted to be located in dendrite and plasma membrane. Expressed in GLR; male-specific anatomical entity; and neurons. Used to study Parkinson's disease and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; drug dependence (multiple); and end stage renal disease. Is an ortholog of human DRD3 (dopamine receptor D3).