dog-1

Caenorhabditis elegans

Predicted to enable DNA helicase activity. Involved in DNA metabolic process and regulation of DNA-templated DNA replication. Predicted to be located in nucleus. Expressed in head and tail. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; Fanconi anemia complementation group J; and cervical squamous cell carcinoma. Is an ortholog of human BRIP1 (BRCA1 interacting helicase 1).

polk-1

Caenorhabditis elegans

Predicted to enable DNA-directed DNA polymerase activity. Involved in embryo development and error-prone translesion synthesis. Predicted to be located in nucleus. Is an ortholog of human POLK (DNA polymerase kappa).

pdi-3

Caenorhabditis elegans

Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including collagen and cuticulin-based cuticle development; egg-laying behavior; and male anatomical structure morphogenesis. Predicted to be located in endoplasmic reticulum. Expressed in hypodermis; intestine; and seam cell. Human ortholog(s) of this gene implicated in autoimmune hepatitis and liver cirrhosis. Is an ortholog of human PDIA3 (protein disulfide isomerase family A member 3).

polh-1

Caenorhabditis elegans

Predicted to enable DNA-directed DNA polymerase activity. Involved in embryo development; error-prone translesion synthesis; and negative regulation of mitotic DNA damage checkpoint. Located in nucleus. Human ortholog(s) of this gene implicated in female breast cancer and xeroderma pigmentosum variant type. Is an ortholog of human POLH (DNA polymerase eta).

lig-4

Caenorhabditis elegans

Predicted to enable ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Expressed in head neurons; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; multiple myeloma; and prostate cancer. Is an ortholog of human LIG4 (DNA ligase 4).

cku-80

Caenorhabditis elegans

Predicted to enable telomeric DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of Ku70:Ku80 complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); chronic obstructive pulmonary disease; and multiple myeloma. Is an ortholog of human XRCC5 (X-ray repair cross complementing 5).