Predicted to enable Hsp70 protein binding activity and ribosome binding activity. Predicted to be involved in 'de novo' cotranslational protein folding. Located in cytosol. Expressed in several structures, including head; muscle cell; neurons; and tail. Is an ortholog of human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2).
Is affected by several genes including dpy-9; dpy-10; and dnj-14 based on microarray studies. Is affected by five chemicals including quercetin; Hydrolyzable Tannins; and paraquat based on microarray studies.
Predicted to enable misfolded protein binding activity; protein kinase inhibitor activity; and protein-folding chaperone binding activity. Involved in PERK-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen. Expressed in head. Is an ortholog of human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3).
Is affected by several genes including npr-15; dnj-14; and mir-243 based on RNA-seq and microarray studies. Is affected by seven chemicals including Cisplatin; Doxorubicin; and resveratrol based on RNA-seq and microarray studies.
Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).
Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Is an ortholog of human TSEN34 (tRNA splicing endonuclease subunit 34).
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including apoptotic process; positive regulation of programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in excretory duct cell. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in osteoporosis and stomach cancer. Is an ortholog of human DBP (D-box binding PAR bZIP transcription factor); HLF (HLF transcription factor, PAR bZIP family member); and TEF (TEF transcription factor, PAR bZIP family member).
Predicted to enable U1 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in Alzheimer's disease; connective tissue disease; and disease of cellular proliferation. Is an ortholog of human SNRPA (small nuclear ribonucleoprotein polypeptide A) and SNRPB2 (small nuclear ribonucleoprotein polypeptide B2).
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of programmed cell death and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is an ortholog of human SCRT1 (scratch family transcriptional repressor 1) and SCRT2 (scratch family transcriptional repressor 2).