dkf-1

Caenorhabditis elegans

Enables protein serine/threonine kinase activity. Involved in several processes, including defense response to Gram-positive bacterium; determination of adult lifespan; and positive regulation of protein import into nucleus. Acts upstream of or within with a positive effect on neuromuscular synaptic transmission. Located in several cellular components, including axon; cell cortex; and somatodendritic compartment. Expressed in neurons.

arrd-17

Caenorhabditis elegans

Enables protein phosphatase 2B binding activity. Predicted to be involved in protein transport. Predicted to be located in cytoplasm. Expressed in nervous system.

eif-2Bbeta

Caenorhabditis elegans

Predicted to enable translation initiation factor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 2. Is an ortholog of human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta).

eif-2Balpha

Caenorhabditis elegans

Enables identical protein binding activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Is an ortholog of human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha).

dkf-2

Caenorhabditis elegans

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in defense response to bacterium; determination of adult lifespan; and signal transduction. Acts upstream of with a negative effect on protein import into nucleus. Located in cytoplasmic side of plasma membrane and cytosol. Part of serine/threonine protein kinase complex. Expressed in AVF; NSM; head neurons; lumbar neurons; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in congenital heart disease. Is an ortholog of human PRKD1 (protein kinase D1); PRKD2 (protein kinase D2); and PRKD3 (protein kinase D3).

metl-2

Caenorhabditis elegans

Predicted to enable tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in methylation. Is an ortholog of human METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine).

ciao-2B

Caenorhabditis elegans

Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is an ortholog of human CIAO2B (cytosolic iron-sulfur assembly component 2B).

C50B6.7

Caenorhabditis elegans

Predicted to enable alpha-amylase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in extracellular space. Expressed in intestine. Is an ortholog of human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B).

eif-2Bepsilon

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 5. Is an ortholog of human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon).

T12D8.10

Caenorhabditis elegans

Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in cytosol and nucleus. Is an ortholog of human BOLA2 (bolA family member 2) and BOLA2B (bolA family member 2B).