ints-6

Caenorhabditis elegans

Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Expressed in several structures, including neurons. Is an ortholog of human INTS6 (integrator complex subunit 6) and INTS6L (integrator complex subunit 6 like).

sna-1

Caenorhabditis elegans

Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of core mediator complex and mediator complex. Expressed in several structures, including germ cell and somatic cell.

rrf-3

Caenorhabditis elegans

Predicted to enable RNA-dependent RNA polymerase activity. Involved in regulatory ncRNA-mediated heterochromatin formation and spermatogenesis. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Expressed in head and tail.

pfd-1

Caenorhabditis elegans

Predicted to enable protein folding chaperone and unfolded protein binding activity. Involved in gonad development. Located in cytoplasm. Expressed in head muscle; pharyngeal muscle cell; and vulval muscle. Is an ortholog of human PFDN1 (prefoldin subunit 1).

drh-1

Caenorhabditis elegans

Predicted to enable ATP binding activity; helicase activity; and nucleic acid binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Is an ortholog of human RIGI (RNA sensor RIG-I).

ung-1

Caenorhabditis elegans

Enables uracil DNA N-glycosylase activity. Involved in base-excision repair. Located in nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Is an ortholog of human UNG (uracil DNA glycosylase).

nud-2

Caenorhabditis elegans

Predicted to enable microtubule binding activity. Involved in GABAergic synaptic transmission; nuclear migration; and synaptic vesicle transport. Located in nuclear envelope. Expressed in several structures, including hypodermal cell; non-striated muscle; pharyngeal-intestinal valve; rectal valve cell; and tail hypodermis. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly 4 and schizophrenia. Is an ortholog of human NDE1 (nudE neurodevelopment protein 1) and NDEL1 (nudE neurodevelopment protein 1 like 1).

nrde-1

Caenorhabditis elegans

Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in nucleus.

dyci-1

Caenorhabditis elegans

Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in transport along microtubule. Predicted to be part of cytoplasmic dynein complex. Expressed in ciliated neurons. Is an ortholog of human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2).

dab-1

Caenorhabditis elegans

Enables clathrin heavy chain binding activity and protein domain specific binding activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; egg-laying behavior; and positive regulation of growth rate. Located in cell cortex; clathrin-coated pit; and cytoplasmic vesicle. Expressed in several structures, including P5.ppp; P7.paa; amphid sheath cell; anchor cell; and vulval cell. Human ortholog(s) of this gene implicated in autistic disorder and spinocerebellar ataxia type 37. Is an ortholog of human DAB1 (DAB adaptor protein 1).