- unc-68 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity and ryanodine-sensitive calcium-release channel activity. Involved in locomotion; positive regulation of programmed cell death; and protein localization to organelle. Located in I band and sarcoplasmic reticulum. Expressed in body wall musculature; intestine; neurons; and non-striated muscle. Used to study congenital myopathy 1A and malignant hyperthermia. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; gestational diabetes; and muscle tissue disease (multiple). Is an ortholog of human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3).
- csq-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calcium ion binding activity. Involved in calcium ion homeostasis. Located in several cellular components, including apical plasma membrane; nucleus; and sarcolemma. Expressed in body wall musculature; isthmus; terminal bulb; and vulval muscle. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 2 and type 2 diabetes mellitus. Is an ortholog of human CASQ1 (calsequestrin 1) and CASQ2 (calsequestrin 2).
- his-68 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Human ortholog(s) of this gene implicated in oral mucosa leukoplakia and oral squamous cell carcinoma. Is an ortholog of human H2AX (H2A.X variant histone).
- trm-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable tRNA (guanine(10)-N2)-methyltransferase activity; tRNA (guanine(26)-N2)-dimethyltransferase activity; and tRNA binding activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Is an ortholog of human TRMT1 (tRNA methyltransferase 1).
- srpa-68 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable signal recognition particle binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Is an ortholog of human SRP68 (signal recognition particle 68).