dcr-1

Caenorhabditis elegans

Enables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleobase-containing compound catabolic process; olfactory learning; and regulatory ncRNA-mediated gene silencing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III).

sls-2.2

Caenorhabditis elegans

Enriched in NSM based on RNA-seq studies. Is affected by daf-12; dcr-1; and etr-1 based on tiling array; microarray; and RNA-seq studies.

K11C4.14

Caenorhabditis elegans

Enriched in AFD and neurons based on RNA-seq and microarray studies. Is affected by prg-1 and dcr-1 based on RNA-seq and microarray studies. Is affected by Sirolimus based on microarray studies.

K02E2.6

Caenorhabditis elegans

Enriched in several structures, including GLR; MSpppaaa; anchor cell; head mesodermal cell; and neurons based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; dys-1; and cyd-1 based on microarray and RNA-seq studies. Is affected by nine chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Aspartic peptidase domain superfamily and gag-polyprotein putative aspartyl protease.

alg-1

Caenorhabditis elegans

Enables RNA binding activity and RNA endonuclease activity. Involved in several processes, including regulation of development, heterochronic; regulatory ncRNA-mediated gene silencing; and vulval development. Located in P-body. Part of RISC complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; gonad; somatic cell; and tail. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Is an ortholog of human AGO2 (argonaute RISC catalytic component 2).

rde-1

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity; RNA endonuclease activity, producing 5'-phosphomonoesters; and siRNA binding activity. Involved in regulatory ncRNA-mediated heterochromatin formation and regulatory ncRNA-mediated post-transcriptional gene silencing. Part of RISC complex. Expressed in male.

pash-1

Caenorhabditis elegans

Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in primary miRNA processing and regulation of developmental process. Predicted to be part of microprocessor complex. Expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in alcohol dependence. Is an ortholog of human DGCR8 (DGCR8 microprocessor complex subunit).

xrn-1

Caenorhabditis elegans

Predicted to enable 5'-3' RNA exonuclease activity and RNA binding activity. Involved in determination of adult lifespan and negative regulation of cytoplasmic mRNA processing body assembly. Predicted to be located in nucleus. Expressed in hypodermis and rectum. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human XRN1 (5'-3' exoribonuclease 1).

rde-4

Caenorhabditis elegans

Enables double-stranded RNA binding activity; protein homodimerization activity; and single-stranded RNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in dystonia 16. Is an ortholog of human PRKRA (protein activator of interferon induced protein kinase EIF2AK2) and TARBP2 (TARBP2 subunit of RISC loading complex).

drh-3

Caenorhabditis elegans

Enables several functions, including ATP hydrolysis activity; ATP-dependent activity, acting on RNA; and RNA binding activity. Involved in P granule assembly; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA processing. Located in P granule; condensed nuclear chromosome; and metaphase plate. Expressed widely. Is an ortholog of human RIGI (RNA sensor RIG-I).