elpc-1

Caenorhabditis elegans

Predicted to enable tRNA binding activity. Involved in several processes, including gamete generation; gene expression; and olfactory learning. Located in cytoplasm; neuron projection; and neuronal cell body. Expressed in CAN; HSN; pharynx; sensory neurons; and vulva. Used to study Riley-Day syndrome. Human ortholog(s) of this gene implicated in several diseases, including Riley-Day syndrome; bone structure disease (multiple); and medulloblastoma. Is an ortholog of human ELP1 (elongator acetyltransferase complex subunit 1).

fat-6

Caenorhabditis elegans

Enables stearoyl-CoA 9-desaturase activity. Involved in innate immune response; long-chain fatty acid biosynthetic process; and post-embryonic development. Predicted to be located in endoplasmic reticulum membrane. Expressed in hypodermis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Is an ortholog of human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5).

elpc-3

Caenorhabditis elegans

Predicted to enable phosphorylase kinase regulator activity. Involved in several processes, including gamete generation; gene expression; and olfactory learning. Predicted to be located in cytoplasm and nucleus. Predicted to be part of elongator holoenzyme complex. Expressed in CAN; HSN; amphid neurons; pharynx; and vulva. Used to study Riley-Day syndrome. Is an ortholog of human ELP3 (elongator acetyltransferase complex subunit 3).

rpsa-1

Caenorhabditis elegans

Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal small subunit assembly. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic small ribosomal subunit. Expressed in tail. Is an ortholog of human RPSA (ribosomal protein SA).

mai-2

Caenorhabditis elegans

Enables ATPase inhibitor activity. Predicted to be involved in heme biosynthetic process. Located in mitochondrion. Expressed in germ line and tail. Is an ortholog of human ATP5IF1 (ATP synthase inhibitory factor subunit 1).

mai-1

Caenorhabditis elegans

Enables ATPase inhibitor activity. Located in cytoplasm. Expressed in coelomocyte; cuticle; hypodermis; rectum; and vulva. Is an ortholog of human ATP5IF1 (ATP synthase inhibitory factor subunit 1).

rplp-0

Caenorhabditis elegans

Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit assembly. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Expressed in somatic cell and tail. Is an ortholog of human RPLP0 (ribosomal protein lateral stalk subunit P0) and RPLP0P6 (ribosomal protein lateral stalk subunit P0 pseudogene 6).

R53.4

Caenorhabditis elegans

Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial membrane. Predicted to be part of proton-transporting ATP synthase complex. Is an ortholog of human ATP5MF (ATP synthase membrane subunit f).

hgrs-1

Caenorhabditis elegans

Enables ubiquitin binding activity. Involved in protein localization to non-motile cilium. Located in early endosome and endosome membrane. Part of ESCRT-0 complex. Expressed in several structures, including coelomocyte; excretory canal; hermaphrodite gonad; intestine; and vulva. Is an ortholog of human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate).

stam-1

Caenorhabditis elegans

Enables ubiquitin binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein localization to non-motile cilium; and response to hermaphrodite contact. Located in cilium and early endosome. Part of ESCRT-0 complex. Expressed in CEM; male gonad; neurons; and pharyngeal-intestinal valve. Used to study polycystic kidney disease. Is an ortholog of human STAM (signal transducing adaptor molecule).