dat-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables amine transmembrane transporter activity; chloride channel activity; and dopamine:sodium symporter activity. Involved in several processes, including cellular response to amphetamine; dopamine uptake involved in synaptic transmission; and regulation of locomotion involved in locomotory behavior. Located in neuron projection membrane; neuronal cell body membrane; and presynaptic membrane. Expressed in dopaminergic neurons; tail; and in male. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; and classic dopamine transporter deficiency syndrome. Is an ortholog of human SLC6A2 (solute carrier family 6 member 2) and SLC6A3 (solute carrier family 6 member 3).