dat-1

Caenorhabditis elegans

Enables amine transmembrane transporter activity; chloride channel activity; and dopamine:sodium symporter activity. Involved in several processes, including cellular response to amphetamine; dopamine uptake involved in synaptic transmission; and regulation of locomotion involved in locomotory behavior. Located in neuron projection membrane; neuronal cell body membrane; and presynaptic membrane. Expressed in dopaminergic neurons; tail; and in male. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; and classic dopamine transporter deficiency syndrome. Is an ortholog of human SLC6A2 (solute carrier family 6 member 2) and SLC6A3 (solute carrier family 6 member 3).

max-5

Caenorhabditis elegans

Y41E3.21

Caenorhabditis elegans

Enriched in DA neuron; VA neuron; and neurons based on microarray studies. Is affected by daf-16; etr-1; and tdp-1 based on RNA-seq and microarray studies. Is affected by silicon dioxide nanoparticle based on RNA-seq studies.

srg-18

Caenorhabditis elegans

Enriched in DA neuron; I5 neuron; SAB; VA neuron; and retrovesicular ganglion based on microarray studies. Is affected by several genes including rrf-3; clk-1; and sir-2.1 based on microarray and RNA-seq studies.

T07H3.7

Caenorhabditis elegans

Enriched in DA neuron; NSM; VA neuron; and intestine based on tiling array studies. Is affected by several genes including rsr-2; dpy-21; and clk-1 based on tiling array; microarray; and RNA-seq studies.

CE7X_3.2

Caenorhabditis elegans

Enriched in DA neuron; VA neuron; and intestine based on tiling array studies. Is affected by several genes including etr-1; hsf-1; and hrpr-1 based on microarray; proteomic; and RNA-seq studies. Is affected by eleven chemicals including Alovudine; stavudine; and Zidovudine based on RNA-seq studies.

F23D12.8

Caenorhabditis elegans

Enriched in DA neuron; VA neuron; and body wall muscle cell based on tiling array studies. Is affected by several genes including rsr-2; csr-1; and spn-4 based on tiling array; microarray; and RNA-seq studies.

C14A6.5

Caenorhabditis elegans

Enriched in DA neuron; NSM; and VA neuron based on tiling array studies. Is affected by several genes including cyc-1; csr-1; and lsm-1 based on microarray and RNA-seq studies. Is affected by six chemicals including methylmercuric chloride; glycine; and cholesterol based on microarray and RNA-seq studies.

nhr-240

Caenorhabditis elegans

Enriched in DA neuron; I5 neuron; SAB; VA neuron; and retrovesicular ganglion based on microarray studies. Is affected by several genes including etr-1; smg-2; and clk-1 based on microarray and RNA-seq studies. Is affected by dibromoacetic acid; tetrabromobisphenol A; and dafa#1 based on microarray studies.

ast-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including nematode pharynx morphogenesis; neuron differentiation; and regulation of nematode male tail tip morphogenesis. Located in nucleus. Expressed in intestine; neurons; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including hereditary lymphedema; pulmonary venoocclusive disease; and thrombocytopenia. Is an ortholog of human FLI1 (Fli-1 proto-oncogene, ETS transcription factor).