Predicted to enable hormone activity. Involved in olfactory learning. Predicted to be located in extracellular region and membrane. Expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system.
Located in plasma membrane. Expressed in body wall musculature; hypodermis; pharynx; and vulva. Is an ortholog of human MEAK7 (MTOR associated protein, eak-7 homolog).
Predicted to enable cytokine activity and transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to cGMP; regulation of gene expression; and response to bacterium. Located in extracellular space. Expressed in coelomocyte; head neurons; pharynx; and in male. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy and vertebral hypersegmentation and orofacial anomalies. Is an ortholog of human GDF11 (growth differentiation factor 11).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; egg-laying behavior; and negative regulation of dauer larval development. Predicted to be part of heteromeric SMAD protein complex. Expressed in several structures, including anal sphincter muscle; excretory duct cell; intestine; nerve ring; and phasmid sheath cell.
Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in several processes, including cellular response to cGMP; determination of adult lifespan; and signal transduction. Located in dendrite; neuronal cell body; and non-motile cilium. Expressed in ADLL; ADLR; ASHL; and ASHR.
Enables ascr#2 binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in G protein-coupled receptor signaling pathway. Located in non-motile cilium. Expressed in head neurons.
Predicted to enable insulin receptor binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of dauer entry; and regulation of synaptic assembly at neuromuscular junction. Acts upstream of with a negative effect on protein import into nucleus. Located in extracellular space and synapse. Expressed in several structures, including distal tip cell; egg-laying apparatus; neurons; pharynx; and ventral nerve cord.