Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Expressed in amphid neurons; anchor cell; hypodermis; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Expressed in dorsal nerve cord; head; neurons; ventral nerve cord; and vulva. Is an ortholog of human RAD23A (RAD23 homolog A, nucleotide excision repair protein).