Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including chromosome organization; regulation of cell cycle; and sexual reproduction. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Expressed in several structures, including EMS; Psub2; germ cell; germ line; and male gonad. Is an ortholog of human CCNB3 (cyclin B3).
Enables cyclin-dependent protein serine/threonine kinase regulator activity and ubiquitin protein ligase binding activity. Involved in mitotic cell cycle; oocyte maturation; and positive regulation of protein phosphorylation. Located in cytoplasm and nucleus. Expressed in germ cell; male gonad; and oocyte. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in several diseases, including in situ carcinoma; renal cell carcinoma; and reproductive organ cancer (multiple). Is an ortholog of human CCNB1 (cyclin B1).
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; male sex determination; and meiotic chromosome segregation. Located in cytoplasm and nucleus. Part of Cul2-RING ubiquitin ligase complex. Expressed in several structures, including P1; P12; P2; germ line; and nerve ring. Is an ortholog of human CUL2 (cullin 2).
Enables cyclin-dependent protein serine/threonine kinase activity and protein kinase binding activity. Involved in several processes, including positive regulation of meiotic nuclear division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and sexual reproduction. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Expressed in embryonic cell and germ cell. Human ortholog(s) of this gene implicated in several diseases, including cervical cancer; hepatobiliary system cancer (multiple); and transitional cell carcinoma. Is an ortholog of human CDK1 (cyclin dependent kinase 1).