Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrial intermembrane space. Is an ortholog of human ENDOG (endonuclease G).
Enables enzyme binding activity. Involved in apoptotic DNA fragmentation and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Located in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; X-linked recessive disease (multiple); and dilated cardiomyopathy 1H. Is an ortholog of human AIFM1 (apoptosis inducing factor mitochondria associated 1).
Enables flap endonuclease activity. Involved in apoptotic DNA fragmentation. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human FEN1 (flap structure-specific endonuclease 1).
Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be located in nucleolus. Predicted to be part of nuclear exosome (RNase complex). Is an ortholog of human EXOSC10 (exosome component 10).
Enables DNA nuclease activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be located in cytosol. Expressed in head and tail. Is an ortholog of human TATDN1 (TatD DNase domain containing 1).
Enables nuclease activity. Involved in apoptotic DNA fragmentation. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be part of catalytic step 2 spliceosome. Is an ortholog of human PPIE (peptidylprolyl isomerase E).