coq-4

Caenorhabditis elegans

Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be extrinsic component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7 and spastic ataxia. Is an ortholog of human COQ4 (coenzyme Q4).

coq-3

Caenorhabditis elegans

Predicted to enable 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity. Involved in nematode larval development and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Is an ortholog of human COQ3 (coenzyme Q3, methyltransferase).

coq-2

Caenorhabditis elegans

Predicted to enable 4-hydroxybenzoate decaprenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Is an ortholog of human COQ2 (coenzyme Q2, polyprenyltransferase).

coq-1

Caenorhabditis elegans

Predicted to enable prenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be part of transferase complex. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2. Is an ortholog of human PDSS1 (decaprenyl diphosphate synthase subunit 1).

coq-8

Caenorhabditis elegans

Predicted to enable ATP binding activity and transferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Expressed in coelomocyte; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9 and primary coenzyme Q10 deficiency 4. Is an ortholog of human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B).

coq-5

Caenorhabditis elegans

Predicted to enable 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Is an ortholog of human COQ5 (coenzyme Q5, methyltransferase).

coq-6

Caenorhabditis elegans

Predicted to enable oxidoreductase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Is an ortholog of human COQ6 (coenzyme Q6, monooxygenase).

D2023.6

Caenorhabditis elegans

Predicted to enable kinase activity. Predicted to be involved in lipid homeostasis and mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Is an ortholog of human ADCK1 (aarF domain containing kinase 1).

sgcb-1

Caenorhabditis elegans

Predicted to be involved in muscle organ development. Predicted to be located in sarcolemma. Predicted to be part of sarcoglycan complex. Expressed in body wall musculature; enteric muscle; neurons; seam cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2E. Is an ortholog of human SGCB (sarcoglycan beta).

vps-53

Caenorhabditis elegans

Involved in positive regulation of locomotion involved in locomotory behavior; regulation of brood size; and regulation of dense core granule transport. Located in perikaryon and perinuclear region of cytoplasm. Part of GARP complex. Expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2E. Is an ortholog of human VPS53 (VPS53 subunit of GARP complex).