che-16

Caenorhabditis elegans

che-13

Caenorhabditis elegans

Involved in chemosensory behavior; cilium organization; and protein localization. Located in axoneme; ciliary basal body; and ciliary transition zone. Part of intraciliary transport particle B. Expressed in neurons. Used to study ciliopathy. Human ortholog(s) of this gene implicated in orofaciodigital syndrome. Is an ortholog of human IFT57 (intraflagellar transport 57).

che-12

Caenorhabditis elegans

Predicted to enable microtubule binding activity. Involved in several processes, including chemotaxis; cilium assembly; and hyperosmotic response. Located in cilium; dendrite; and neuronal cell body. Expressed in amphid neurons and phasmid neurons. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Joubert syndrome. Is an ortholog of human TOGARAM1 (TOG array regulator of axonemal microtubules 1) and TOGARAM2 (TOG array regulator of axonemal microtubules 2).

che-1

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including response to alkaline pH; response to metal ion; and response to methionine. Predicted to be located in nucleus. Expressed in ASEL and ASER.

che-10

Caenorhabditis elegans

Involved in cilium assembly. Located in ciliary basal body and ciliary transition zone. Is an ortholog of human CEP250 (centrosomal protein 250) and CROCC (ciliary rootlet coiled-coil, rootletin).

che-14

Caenorhabditis elegans

Predicted to enable transmembrane transporter activity. Predicted to be involved in smoothened signaling pathway. Located in apical plasma membrane. Expressed in epithelial cell; excretory system; hypodermis; rectum; and vulva. Is an ortholog of human DISP1 (dispatched RND transporter family member 1) and DISP2 (dispatched RND transporter family member 2).

che-11

Caenorhabditis elegans

Involved in several processes, including dauer entry; positive regulation of intracellular transport; and response to stress. Located in non-motile cilium. Expressed in head and neurons. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Is an ortholog of human IFT140 (intraflagellar transport 140).

che-3

Caenorhabditis elegans

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in several processes, including dauer entry; non-motile cilium assembly; and positive regulation of dauer larval development. Located in non-motile cilium. Expressed in I4 neuron; PDEL; PDER; and nerve ring. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 3. Is an ortholog of human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1).

che-2

Caenorhabditis elegans

Involved in several processes, including dauer larval development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of locomotion involved in locomotory behavior. Located in ciliary basal body and non-motile cilium. Expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Is an ortholog of human IFT80 (intraflagellar transport 80).

osm-12

Caenorhabditis elegans

Involved in chemotaxis; cilium organization; and protein localization to microvillus membrane. Located in ciliary basal body; neuron projection; and non-motile cilium. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 7. Is an ortholog of human BBS7 (Bardet-Biedl syndrome 7).