cgh-1

Caenorhabditis elegans

Predicted to enable RNA helicase activity and mRNA binding activity. Involved in several processes, including P-body assembly; determination of adult lifespan; and negative regulation of translation. Located in P granule; P-body; and cytoplasmic stress granule. Part of ribonucleoprotein complex. Expressed in several structures, including Z2; Z3; germ line; gonad; and neurons. Is an ortholog of human DDX6 (DEAD-box helicase 6).

car-1

Caenorhabditis elegans

Enables RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in positive regulation of gene expression. Located in endoplasmic reticulum and intracellular non-membrane-bounded organelle. Part of ribonucleoprotein complex. Expressed in germ line; gonad; neurons; somatic cell; and touch receptor neurons. Is an ortholog of human LSM14B (LSM family member 14B).

sna-1

Caenorhabditis elegans

Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of core mediator complex and mediator complex. Expressed in several structures, including germ cell and somatic cell.

rrf-3

Caenorhabditis elegans

Predicted to enable RNA-dependent RNA polymerase activity. Involved in regulatory ncRNA-mediated heterochromatin formation and spermatogenesis. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Expressed in head and tail.

pfd-1

Caenorhabditis elegans

Predicted to enable protein folding chaperone and unfolded protein binding activity. Involved in gonad development. Located in cytoplasm. Expressed in head muscle; pharyngeal muscle cell; and vulval muscle. Is an ortholog of human PFDN1 (prefoldin subunit 1).

drh-1

Caenorhabditis elegans

Predicted to enable ATP binding activity; helicase activity; and nucleic acid binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Is an ortholog of human RIGI (RNA sensor RIG-I).

ung-1

Caenorhabditis elegans

Enables uracil DNA N-glycosylase activity. Involved in base-excision repair. Located in nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Is an ortholog of human UNG (uracil DNA glycosylase).

nud-2

Caenorhabditis elegans

Predicted to enable microtubule binding activity. Involved in GABAergic synaptic transmission; nuclear migration; and synaptic vesicle transport. Located in nuclear envelope. Expressed in several structures, including hypodermal cell; non-striated muscle; pharyngeal-intestinal valve; rectal valve cell; and tail hypodermis. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly 4 and schizophrenia. Is an ortholog of human NDE1 (nudE neurodevelopment protein 1) and NDEL1 (nudE neurodevelopment protein 1 like 1).

nhl-2

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity. Involved in positive regulation of development, heterochronic; protein localization to cell cortex; and regulation of establishment of cell polarity. Located in P granule and P-body. Expressed in several structures, including germ line. Is an ortholog of human TRIM45 (tripartite motif containing 45).

nrde-1

Caenorhabditis elegans

Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in nucleus.