unc-89

Caenorhabditis elegans

Enables MATH domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including myofibril assembly; nematode pharyngeal gland morphogenesis; and regulation of striated muscle contraction. Located in M band. Expressed in alimentary muscle; gonad; tail; and vulval muscle. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Is an ortholog of human SPEG (striated muscle enriched protein kinase).

ceh-89

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in neurons. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is an ortholog of human HOPX (HOP homeobox).

cel-1

Caenorhabditis elegans

Enables polynucleotide 5'-phosphatase activity. Involved in polynucleotide 5' dephosphorylation and positive regulation of gene expression. Located in nucleus. Expressed in tail. Is an ortholog of human RNGTT (RNA guanylyltransferase and 5'-phosphatase).

nlp-88

Caenorhabditis elegans

Predicted to be involved in neuropeptide signaling pathway.

C26D10.7

Caenorhabditis elegans

Predicted to enable kinase activity. Predicted to be involved in syncytium formation by plasma membrane fusion. Predicted to be located in cell-cell contact zone.

hrdl-1

Caenorhabditis elegans

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Is an ortholog of human AMFR (autocrine motility factor receptor).

kars-1

Caenorhabditis elegans

Predicted to enable lysine-tRNA ligase activity and tRNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode larval development; and regulation of brood size. Predicted to be located in cytosol and mitochondrion. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Expressed in tail. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Is an ortholog of human KARS1 (lysyl-tRNA synthetase 1).

T18D3.1

Caenorhabditis elegans

Enriched in several structures, including ABplaapaaa; ABplapppapp; ABpraapaaa; AFD; and germ line based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; puf-8; and nuo-6 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by ten chemicals including D-glucose; iron oxide nanoparticle; and Alovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: WD repeat-containing protein 89; WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD domain, G-beta repeat; and WD40-repeat-containing domain superfamily.

klp-11

Caenorhabditis elegans

Enables microtubule motor activity. Involved in microtubule-based movement. Part of axonemal heterotrimeric kinesin-II complex. Expressed in amphid neurons; dorsal nerve cord; inner labial neurons; phasmid neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Is an ortholog of human KIF3B (kinesin family member 3B) and KIF3C (kinesin family member 3C).

scpl-1

Caenorhabditis elegans

Enables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in regulation of egg-laying behavior. Located in I band and M band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like).