let-63

Caenorhabditis elegans

mir-63

Caenorhabditis elegans

Expressed in neurons.

his-63

Caenorhabditis elegans

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Is an ortholog of several human genes including H3C1 (H3 clustered histone 1); H3C3 (H3 clustered histone 3); and H3C4 (H3 clustered histone 4).

cel-1

Caenorhabditis elegans

Enables polynucleotide 5'-phosphatase activity. Involved in polynucleotide 5' dephosphorylation and positive regulation of gene expression. Located in nucleus. Expressed in tail. Is an ortholog of human RNGTT (RNA guanylyltransferase and 5'-phosphatase).

ceh-63

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ganglia; head; tail; uterus; and in male.

unc-63

Caenorhabditis elegans

Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; cholinergic synaptic transmission; and regulation of multicellular organismal process. Located in neuromuscular junction and postsynaptic membrane. Expressed in ganglia; head muscle; motor neurons; non-striated muscle; and ventral nerve cord. Used to study alcohol use disorder and congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).

ampd-1

Caenorhabditis elegans

Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including congestive heart failure; hereditary spastic paraplegia 63; and pontocerebellar hypoplasia type 9. Is an ortholog of human AMPD2 (adenosine monophosphate deaminase 2).

cpx-1

Caenorhabditis elegans

Predicted to enable SNARE binding activity. Predicted to be involved in regulation of neurotransmitter secretion and synaptic vesicle exocytosis. Located in axon and synapse. Expressed in head neurons; motor neurons; nervous system; tail neurons; and ventral cord neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Is an ortholog of human CPLX1 (complexin 1) and CPLX2 (complexin 2).

acs-17

Caenorhabditis elegans

Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to be located in endoplasmic reticulum; lipid droplet; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including lung cancer; non-syndromic X-linked intellectual disability 63; and prostate cancer. Is an ortholog of human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4).

acs-4

Caenorhabditis elegans

Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Located in lipid droplet. Expressed in gonadal sheath cell; hypodermis; intestine; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including lung cancer; non-syndromic X-linked intellectual disability 63; and prostate cancer. Is an ortholog of human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4).