Enables several functions, including BH domain binding activity; peptidase activator activity; and small molecule binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of synapse pruning; and regulation of apoptotic process. Located in several cellular components, including cytoplasm; membrane; and nucleus. Part of caspase complex. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in Parkinson's disease; lung non-small cell carcinoma; and pancreatic cancer. Is an ortholog of human APAF1 (apoptotic peptidase activating factor 1).
Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process.
Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve.
Enables identical protein binding activity and phosphatidylserine binding activity. Involved in engulfment of apoptotic cell. Located in plasma membrane. Expressed in engulfing cell. Is an ortholog of human JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase).
Enables GTPase activator activity and protein sequestering activity. Involved in several processes, including mitophagy; positive regulation of reproductive process; and regulation of cellular component organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and perinuclear region of cytoplasm. Expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; B-cell lymphoma (multiple); colorectal adenocarcinoma; and transient cerebral ischemia. Is an ortholog of human BCL2L2 (BCL2 like 2) and BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough).
Predicted to be involved in iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is an ortholog of human CIAO1 (cytosolic iron-sulfur assembly component 1).
Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is an ortholog of human CIAO2B (cytosolic iron-sulfur assembly component 2B).
Predicted to be involved in protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Is an ortholog of human BOLA3 (bolA family member 3).
Enables phosphatidylinositol phosphate binding activity; proline-rich region binding activity; and small GTPase binding activity. Involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and left/right axis specification. Located in cytoplasm and plasma membrane. Part of guanyl-nucleotide exchange factor complex. Expressed in intestinal cell and tail. Is an ortholog of human ELMO1 (engulfment and cell motility 1); ELMO2 (engulfment and cell motility 2); and ELMO3 (engulfment and cell motility 3).