Enables protein kinase activity. Involved in several processes, including GABAergic synaptic transmission; regulation of cellular localization; and regulation of synapse organization. Located in axon and synapse. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Is an ortholog of human CDK5 (cyclin dependent kinase 5).
Enables cyclin-dependent protein serine/threonine kinase activity and protein kinase binding activity. Involved in several processes, including positive regulation of meiotic nuclear division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and sexual reproduction. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Expressed in embryonic cell and germ cell. Human ortholog(s) of this gene implicated in several diseases, including cervical cancer; hepatobiliary system cancer (multiple); and transitional cell carcinoma. Is an ortholog of human CDK1 (cyclin dependent kinase 1).
Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including pseudocleavage; regulation of mitotic cell cycle; and regulation of protein localization. Part of chromatin.
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Expressed in anchor cell and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87 and dilated cardiomyopathy. Is an ortholog of human CDK19 (cyclin dependent kinase 19) and CDK8 (cyclin dependent kinase 8).
Enables protein serine/threonine kinase activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of brood size; and positive regulation of cell cycle process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Expressed in gonad; intestine; neurons; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6).
Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in embryo development; germ cell development; and nematode larval development. Part of euchromatin. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in congestive heart failure. Is an ortholog of human CDK9 (cyclin dependent kinase 9).
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; kinase activity; and metal ion binding activity. Predicted to be involved in DNA repair and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH holo complex. Is an ortholog of human MNAT1 (MNAT1 component of CDK activating kinase).
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of DNA-templated transcription, elongation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Expressed widely. Is an ortholog of human CCNT1 (cyclin T1).