cdc-48.1

Caenorhabditis elegans

Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ERAD pathway; determination of adult lifespan; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. Expressed in several structures, including body wall musculature; germ line; and gonad. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1. Is an ortholog of human VCP (valosin containing protein).

cdc-26

Caenorhabditis elegans

Predicted to be involved in cell division; meiotic cell cycle; and protein ubiquitination. Predicted to be located in nucleus. Expressed in germ line.

cdc-25.3

Caenorhabditis elegans

Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Located in nucleus. Expressed in ABa; ABp; and germ line. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive polycystic kidney disease; endometrial hyperplasia; and reproductive organ cancer (multiple). Is an ortholog of human CDC25A (cell division cycle 25A); CDC25B (cell division cycle 25B); and CDC25C (cell division cycle 25C).

chin-1

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Involved in protein localization. Located in cell cortex. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Is an ortholog of human CHN1 (chimerin 1).

cdc-48.2

Caenorhabditis elegans

Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ERAD pathway; negative regulation of protein localization to centrosome; and protein localization to nucleus. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Expressed in body wall musculature and germ line. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1. Is an ortholog of human VCP (valosin containing protein).

apc-2

Caenorhabditis elegans

Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in metaphase/anaphase transition of mitotic cell cycle and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; lung disease (multiple); and primary angle-closure glaucoma. Is an ortholog of human ANAPC2 (anaphase promoting complex subunit 2).

madd-3

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleus. Expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. Is an ortholog of human CLK2 (CDC like kinase 2).

cdc-14

Caenorhabditis elegans

Enables phosphoprotein phosphatase activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; mitotic spindle midzone assembly; and regulation of cell cycle process. Located in microtubule cytoskeleton; midbody; and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32 and renal cell carcinoma. Is an ortholog of human CDC14A (cell division cycle 14A).

cgef-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in protein localization. Located in cell cortex and nucleoplasm. Expressed in hermaphrodite gonad; neurons; somatic gonad precursor; and vulva. Is an ortholog of human MCF2 (MCF.2 cell line derived transforming sequence); MCF2L (MCF.2 cell line derived transforming sequence like); and MCF2L2 (MCF.2 cell line derived transforming sequence-like 2).

orc-1

Caenorhabditis elegans

Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Is an ortholog of human ORC1 (origin recognition complex subunit 1).