cca-1

Caenorhabditis elegans

Predicted to enable low voltage-gated calcium channel activity. Involved in membrane depolarization; positive regulation of action potential; and regulation of nematode pharyngeal pumping. Predicted to be located in neuron projection. Predicted to be part of voltage-gated sodium channel complex. Expressed in several structures, including alimentary muscle; distal tip cell; pharyngeal neurons; serotonergic neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including cerebellar ataxia type 42; childhood absence epilepsy; and primary hyperaldosteronism. Is an ortholog of human CACNA1I (calcium voltage-gated channel subunit alpha1 I).

hpo-31

Caenorhabditis elegans

Predicted to enable tRNA binding activity. Predicted to be involved in mitochondrial tRNA 3'-end processing and tRNA 3'-terminal CCA addition. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Is an ortholog of human TRNT1 (tRNA nucleotidyl transferase 1).