Enables Wnt-protein binding activity; frizzled binding activity; and transmembrane receptor protein tyrosine kinase activity. Involved in generation of neurons and neuroblast migration. Located in axon; neuromuscular junction; and somatodendritic compartment. Expressed in several structures, including QL.aa; head; neurons; pharynx; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; and brachydactyly type B1. Is an ortholog of human ROR1 (receptor tyrosine kinase like orphan receptor 1).
Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of intracellular signal transduction; and response to alkaline pH. Expressed in AFDL; AFDR; and head. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Is an ortholog of human PDE1A (phosphodiesterase 1A) and PDE1B (phosphodiesterase 1B).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Expressed in pharyngeal muscle cell and rectal epithelium. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).
Enables GTPase activating protein binding activity. Involved in molting cycle. Is an ortholog of human RABEP1 (rabaptin, RAB GTPase binding effector protein 1).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and ovulation. Expressed in spermatheca. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).
Enables calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in CAMKK-AMPK signaling cascade. Located in cytoplasm and nucleus. Expressed in head neurons; tail neurons; and vulval muscle. Human ortholog(s) of this gene implicated in high grade glioma. Is an ortholog of human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1).