such-1

Caenorhabditis elegans

Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Expressed in germ line; head neurons; sperm; and vulval precursor cell. Is an ortholog of human ANAPC5 (anaphase promoting complex subunit 5).

aap-1

Caenorhabditis elegans

Enables protein kinase binding activity. Involved in dauer larval development; determination of adult lifespan; and insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Expressed in anchor cell; intestine; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; SHORT syndrome; arthritis (multiple); and carcinoma (multiple). Is an ortholog of human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2).

abi-1

Caenorhabditis elegans

Enables SH3 domain binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of endocytosis; presynaptic actin cytoskeleton organization; and synaptic vesicle clustering. Located in axon; cytoplasm; and somatodendritic compartment. Expressed in coelomocyte; head neurons; and ventral cord neurons. Is an ortholog of human ABI1 (abl interactor 1).

abtm-1

Caenorhabditis elegans

Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in intracellular iron ion homeostasis. Located in mitochondrion. Expressed in coelomocyte; hypodermis; intestine; and spermatheca. Used to study X-linked sideroblastic anemia with ataxia. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Is an ortholog of human ABCB7 (ATP binding cassette subfamily B member 7).

abts-1

Caenorhabditis elegans

Enables chloride transmembrane transporter activity and solute:inorganic anion antiporter activity. Involved in several processes, including cholinergic synaptic transmission; regulation of GABAergic synaptic transmission; and response to serotonin. Predicted to be located in plasma membrane. Expressed in HSN; accessory cell; body wall musculature; head; and pharynx. Human ortholog(s) of this gene implicated in cholangiocarcinoma and renal tubular acidosis. Is an ortholog of human SLC4A10 (solute carrier family 4 member 10); SLC4A7 (solute carrier family 4 member 7); and SLC4A8 (solute carrier family 4 member 8).

acdh-1

Caenorhabditis elegans

Predicted to enable acyl-CoA dehydrogenase activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in mitochondrion. Expressed in E lineage cell; hypodermis; and neurons. Is an ortholog of human ACADSB (acyl-CoA dehydrogenase short/branched chain).

acy-1

Caenorhabditis elegans

Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in plasma membrane. Expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in mood disorder. Is an ortholog of human ADCY9 (adenylate cyclase 9).

adal-1

Caenorhabditis elegans

Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Is an ortholog of human MAPDA (N6-Methyl-AMP deaminase).

add-1

Caenorhabditis elegans

Predicted to enable actin filament binding activity. Involved in actin filament bundle organization; memory; and receptor localization to synapse. Located in postsynaptic density. Expressed in GLR; coelomocyte; and neurons. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); and familial combined hyperlipidemia. Is an ortholog of human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3).

adss-1

Caenorhabditis elegans

Predicted to enable adenylosuccinate synthase activity. Predicted to be involved in 'de novo' AMP biosynthetic process and IMP metabolic process. Predicted to be located in cytoplasm. Is an ortholog of human ADSS1 (adenylosuccinate synthase 1).