bec-1

Caenorhabditis elegans

Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Involved in several processes, including determination of adult lifespan; gamete generation; and nematode male tail tip morphogenesis. Located in cytoplasmic vesicle and nucleus. Expressed in several structures, including intestine; nervous system; pharynx; tail; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Barrett's esophagus; Machado-Joseph disease; and adenocarcinoma (multiple). Is an ortholog of human BECN1 (beclin 1).

atf-2

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and protein heterodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in digestive tract; egg-laying apparatus; excretory system; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in severe acute respiratory syndrome. Is an ortholog of human NFIL3 (nuclear factor, interleukin 3 regulated) and NFILZ (NFIL3 like basic leucine zipper).

cnb-1

Caenorhabditis elegans

Enables calcium ion binding activity. Predicted to be involved in calcineurin-mediated signaling. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Expressed in several structures, including germ line; gonad; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Is an ortholog of human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha).

epg-8

Caenorhabditis elegans

Predicted to enable phosphatidylinositol 3-kinase regulator activity and protein-membrane adaptor activity. Involved in macroautophagy; positive regulation of autophagy; and positive regulation of embryonic development. Located in cytoplasm. Expressed in neurons and pharyngeal muscle cell.

lipl-4

Caenorhabditis elegans

Enables triglyceride lipase activity. Involved in cellular lipid metabolic process; determination of adult lifespan; and positive regulation of macroautophagy. Located in lysosome. Expressed in intestine and seam cell. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Is an ortholog of several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J).

tax-6

Caenorhabditis elegans

Enables calcium ion binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including determination of adult lifespan; male mating behavior; and response to temperature stimulus. Located in several cellular components, including neuronal cell body; nucleus; and plasma membrane bounded cell projection. Expressed in several structures, including germ line; head neurons; muscle cell; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including aortic valve stenosis; cholangiocarcinoma; and developmental and epileptic encephalopathy 91. Is an ortholog of human PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma).