osm-12

Caenorhabditis elegans

Involved in chemotaxis; cilium organization; and protein localization to microvillus membrane. Located in ciliary basal body; neuron projection; and non-motile cilium. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 7. Is an ortholog of human BBS7 (Bardet-Biedl syndrome 7).

bbs-9

Caenorhabditis elegans

Predicted to be involved in cilium assembly. Located in ciliary basal body. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 9; craniosynostosis; and primary ovarian insufficiency. Is an ortholog of human BBS9 (Bardet-Biedl syndrome 9).

bbs-5

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in cilium assembly and intracellular transport. Located in cilium. Expressed in head; neurons; outer labial neurons; and tail. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 5. Is an ortholog of human BBS5 (Bardet-Biedl syndrome 5).

bbs-8

Caenorhabditis elegans

Involved in several processes, including cilium organization; olfactory learning; and regulation of cellular localization. Located in cilium and dendrite terminus. Expressed in ciliated neurons; head; and sensory neurons. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 8 and retinitis pigmentosa 51. Is an ortholog of human TTC8 (tetratricopeptide repeat domain 8).

bbs-2

Caenorhabditis elegans

Involved in non-motile cilium assembly. Located in ciliary basal body and neuron projection. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 2; obesity; and retinitis pigmentosa 74. Is an ortholog of human BBS2 (Bardet-Biedl syndrome 2).

bbs-1

Caenorhabditis elegans

Predicted to enable patched binding activity and smoothened binding activity. Involved in non-motile cilium assembly. Acts upstream of or within intraciliary retrograde transport and protein localization to cilium. Located in axoneme; ciliary basal body; and neuron projection. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome; alcohol use disorder; and obesity. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 1 and obesity. Is an ortholog of human BBS1 (Bardet-Biedl syndrome 1).

nphp-1

Caenorhabditis elegans

Involved in several processes, including determination of adult lifespan; male mating behavior; and non-motile cilium assembly. Located in cilium. Expressed in ciliated neurons; cloacal ganglion; postcloacal sensillum; and sensory neurons. Used to study nephronophthisis. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 4; Senior-Loken syndrome; and nephronophthisis 1. Is an ortholog of human NPHP1 (nephrocystin 1).

bbs-4

Caenorhabditis elegans

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in centrosome cycle; cilium assembly; and protein localization to cilium. Located in ciliary basal body. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 4 and morbid obesity. Is an ortholog of human BBS4 (Bardet-Biedl syndrome 4).

daf-19

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; male mating behavior; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in nucleus. Expressed in several structures, including body wall musculature; excretory cell; intestine; neurons; and somatic nervous system. Is an ortholog of human RFX3 (regulatory factor X3).

zyg-7

Caenorhabditis elegans