sptl-3

Caenorhabditis elegans

Predicted to enable serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Is an ortholog of human SPTLC2 (serine palmitoyltransferase long chain base subunit 2) and SPTLC3 (serine palmitoyltransferase long chain base subunit 3).

sptl-2

Caenorhabditis elegans

Predicted to enable serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Is an ortholog of human SPTLC2 (serine palmitoyltransferase long chain base subunit 2) and SPTLC3 (serine palmitoyltransferase long chain base subunit 3).

ccdc-149

Caenorhabditis elegans

Located in ciliary base. Expressed in neurons. Is an ortholog of human CCDC149 (coiled-coil domain containing 149).

rpi-2

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Involved in protein localization to non-motile cilium. Located in cilium and periciliary membrane compartment. Human ortholog(s) of this gene implicated in retinitis pigmentosa 2. Is an ortholog of human RP2 (RP2 activator of ARL3 GTPase).

cfap-36

Caenorhabditis elegans

Located in axoneme and ciliary base. Expressed in ciliated neurons. Is an ortholog of human CFAP36 (cilia and flagella associated protein 36).

mir-2

Caenorhabditis elegans

Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Expressed in neurons.

rpn-1

Caenorhabditis elegans

Predicted to enable enzyme regulator activity. Involved in nematode larval development. Predicted to be located in nucleus and proteasome storage granule. Predicted to be part of proteasome regulatory particle, base subcomplex. Is an ortholog of human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2).

C10G11.8

Caenorhabditis elegans

Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex.

rpi-1

Caenorhabditis elegans

Predicted to be involved in intracellular signal transduction. Located in axonemal microtubule; ciliary base; and ciliary transition zone. Expressed in ciliated neurons. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; and dyslexia. Is an ortholog of human DCDC2 (doublecortin domain containing 2); DCDC2B (doublecortin domain containing 2B); and DCDC2C (doublecortin domain containing 2C).

ifta-2

Caenorhabditis elegans

Predicted to enable GTPase activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and insulin-like growth factor receptor signaling pathway. Located in axoneme and ciliary base. Expressed in amphid neurons and phasmid neurons. Is an ortholog of human IFT22 (intraflagellar transport 22).