Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including nematode larval development; reproductive behavior; and response to stress. Located in several cellular components, including adherens junction; cytosol; and nucleus. Expressed in several structures, including gonad; intestine; and vulva.
Predicted to enable actin binding activity and phospholipid binding activity. Involved in cell projection assembly and membrane organization. Located in cytoplasmic side of plasma membrane and filopodium. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Is an ortholog of human MTSS2 (MTSS I-BAR domain containing 2).
Is affected by several genes including wdr-5.1; bar-1; and daf-16 based on microarray and RNA-seq studies. Is affected by allantoin based on microarray studies.