Enables extracellularly glutamate-gated chloride channel activity. Involved in several processes, including locomotion involved in locomotory behavior; regulation of nematode pharyngeal pumping; and response to xenobiotic stimulus. Located in membrane. Expressed in head; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3).
Enables extracellularly glutamate-gated chloride channel activity; glutamate binding activity; and identical protein binding activity. Involved in chloride transmembrane transport; locomotion involved in locomotory behavior; and protein complex oligomerization. Located in plasma membrane. Expressed in body wall musculature; head neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2) and GLRA3 (glycine receptor alpha 3).
Predicted to enable neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in neuron projection; plasma membrane; and synapse. Predicted to be part of transmembrane transporter complex. Expressed in AIYL and AIYR.
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Expressed in pharyngeal muscle cell and rectal epithelium. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).
Enables GTPase activating protein binding activity. Involved in molting cycle. Is an ortholog of human RABEP1 (rabaptin, RAB GTPase binding effector protein 1).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and ovulation. Expressed in spermatheca. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).