srj-45

Caenorhabditis elegans

Predicted to be located in membrane. Expressed in AVM; amphid neurons; head neurons; and seam cell.

M176.15

Caenorhabditis elegans

Enriched in AVM; PHCL; PVM; and RIPL based on single-cell RNA-seq studies. Is affected by mrpl-2 and ogt-1 based on RNA-seq studies.

D1022.17

Caenorhabditis elegans

Enriched in AVM; PHCL; PVM; and RIPL based on single-cell RNA-seq studies. Is affected by several genes including spr-5; unc-30; and ilc-17.1 based on RNA-seq studies.

lin-30

Caenorhabditis elegans

Y45F10C.1

Caenorhabditis elegans

Enriched in AFD; AVM; MSpaaaaa; sensory neurons; and in male based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including numr-2; numr-1; and nuo-6 based on microarray; tiling array; and RNA-seq studies. Is affected by fifteen chemicals including methylmercuric chloride; Psoralens; and allantoin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Peptidase C14A; SPK domain; and Domain of unknown function (DUF545).

pig-1

Caenorhabditis elegans

Enables protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; hemidesmosome assembly; and regulation of apoptotic process. Located in centrosome and cytoplasm. Expressed in several structures, including AVM; Q lineage cell; QL.aa; QL.pp; and nerve ring neurons. Is an ortholog of human MELK (maternal embryonic leucine zipper kinase).

eva-1

Caenorhabditis elegans

Predicted to enable carbohydrate binding activity. Located in M band; cell junction; and striated muscle dense body. Expressed in body wall musculature; hypodermis; pharyngeal muscle cell; and ventral nerve cord. Is an ortholog of human EVA1C (eva-1 homolog C).

cysl-1

Caenorhabditis elegans

Enables cysteine synthase activity and enzyme binding activity. Involved in cysteine biosynthetic process from serine and response to hypoxia. Located in striated muscle dense body. Expressed in body wall musculature; head ganglion; hypodermis; neurons; and non-striated muscle.

ptl-1

Caenorhabditis elegans

Enables kinesin binding activity and microtubule binding activity. Involved in microtubule polymerization and positive regulation of nematode male tail tip morphogenesis. Located in axon. Expressed in intestinal muscle; neurons; and tail. Used to study amyotrophic lateral sclerosis and tauopathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease (multiple); breast cancer; and late onset Parkinson's disease. Is an ortholog of human MAP4 (microtubule associated protein 4).

cle-1

Caenorhabditis elegans

Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including cholinergic synaptic transmission; generation of neurons; and inductive cell migration. Located in basement membrane and cell junction. Expressed in several structures, including basal lamina; head mesodermal cell; neurons; smooth muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Is an ortholog of human COL15A1 (collagen type XV alpha 1 chain) and COL18A1 (collagen type XVIII alpha 1 chain).