lgg-3

Caenorhabditis elegans

Predicted to contribute to Atg8-family ligase activity. Involved in cellular response to toxic substance; determination of adult lifespan; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Is an ortholog of human ATG12 (autophagy related 12).

atg-4.1

Caenorhabditis elegans

Enables cysteine-type endopeptidase activity. Involved in aggrephagy and protein processing. Located in cytoplasm. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; head muscle; and somatic nervous system. Is an ortholog of human ATG4A (autophagy related 4A cysteine peptidase).

atg-16.1

Caenorhabditis elegans

Predicted to enable protein-membrane adaptor activity. Involved in aggrephagy. Located in cytoplasm. Expressed in embryonic cell; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Is an ortholog of human ATG16L1 (autophagy related 16 like 1).

atg-4.2

Caenorhabditis elegans

Enables cysteine-type endopeptidase activity. Predicted to be involved in macroautophagy and protein processing. Predicted to be located in cytoplasm. Expressed in embryonic cell; gonad; and oocyte. Is an ortholog of human ATG4D (autophagy related 4D cysteine peptidase).

atg-3

Caenorhabditis elegans

Predicted to enable Atg8-family ligase activity. Involved in macroautophagy. Predicted to be located in cytosol and phagophore assembly site. Is an ortholog of human ATG3 (autophagy related 3).

atg-16.2

Caenorhabditis elegans

Predicted to enable protein-membrane adaptor activity. Involved in defense response to Gram-positive bacterium; gamete generation; and macroautophagy. Located in cytoplasm. Expressed in body wall musculature; embryonic cell; intestine; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Is an ortholog of human ATG16L1 (autophagy related 16 like 1) and ATG16L2 (autophagy related 16 like 2).

aat-3

Caenorhabditis elegans

Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); esophagitis; and glioblastoma. Is an ortholog of human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8).

aat-1

Caenorhabditis elegans

Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Expressed in egg-laying apparatus; head motor neurons; and tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and lysinuric protein intolerance. Is an ortholog of human SLC7A8 (solute carrier family 7 member 8).

atg-2

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Involved in positive regulation of autophagy. Predicted to be located in phagophore and phagophore assembly site. Expressed in AIYL and AIYR. Is an ortholog of human ATG2A (autophagy related 2A).

atg-18

Caenorhabditis elegans

Enables phosphatidylinositol phosphate binding activity. Involved in several processes, including determination of adult lifespan; gamete generation; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in phagocytic vesicle. Expressed in several structures, including head and tail. Used to study Huntington's disease. Is an ortholog of human WIPI2 (WD repeat domain, phosphoinositide interacting 2).