atf-4

Caenorhabditis elegans

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in hydrogen sulfide biosynthetic process and positive regulation of gene expression. Located in nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4) and ATF5 (activating transcription factor 5).

grl-32

Caenorhabditis elegans

Is affected by several genes including atf-7; srbc-48; and mrps-5 based on RNA-seq and microarray studies. Is affected by seven chemicals including multi-walled carbon nanotube; metformin; and Sirolimus based on RNA-seq and microarray studies.

atf-2

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and protein heterodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in digestive tract; egg-laying apparatus; excretory system; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in severe acute respiratory syndrome. Is an ortholog of human NFIL3 (nuclear factor, interleukin 3 regulated) and NFILZ (NFIL3 like basic leucine zipper).

T28C6.11

Caenorhabditis elegans

Enriched in several structures, including ABalpapaap; MSpppaaa; excretory cell; head mesodermal cell; and rectal epithelial cell based on single-cell RNA-seq and microarray studies. Is affected by several genes including atf-7; spr-5; and emr-1 based on RNA-seq and microarray studies. Is affected by rifampin and allantoin based on RNA-seq studies.

Y71A12B.14

Caenorhabditis elegans

Enriched in AVK and head mesodermal cell based on RNA-seq studies. Is affected by several genes including nuo-6; atf-6; and etr-1 based on RNA-seq and microarray studies.

ZK1127.12

Caenorhabditis elegans

Enriched in several structures, including ABalaapppa; ABalapaapa; ABalppppppp; PLM; and germ line based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including atf-7; isp-1; and rpl-5 based on microarray and RNA-seq studies. Is affected by nine chemicals including hydrogen sulfide; rotenone; and stavudine based on microarray and RNA-seq studies.

F55G11.3

Caenorhabditis elegans

Is affected by several genes including cyc-1; atf-7; and etr-1 based on microarray and RNA-seq studies. Is affected by six chemicals including allantoin; Sirolimus; and Psoralens based on RNA-seq studies.

atf-6

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ATF6-mediated unfolded protein response; determination of adult lifespan; and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in nucleus. Expressed in several structures, including intestine; muscle cell; pharyngeal gland cell; rectum; and vulva. Human ortholog(s) of this gene implicated in achromatopsia 7. Is an ortholog of human ATF6 (activating transcription factor 6) and ATF6B (activating transcription factor 6 beta).

F22B8.4

Caenorhabditis elegans

Is affected by several genes including nuo-6; atfs-1; and atf-7 based on microarray and RNA-seq studies. Is affected by ten chemicals including rotenone; Alovudine; and stavudine based on RNA-seq and microarray studies.

C09F9.4

Caenorhabditis elegans

Is affected by several genes including atf-7; etr-1; and crh-1 based on microarray and RNA-seq studies. Is affected by seven chemicals including methylmercury hydroxide; Psoralens; and allantoin based on RNA-seq and microarray studies.