Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including nematode pharynx morphogenesis; neuron differentiation; and regulation of nematode male tail tip morphogenesis. Located in nucleus. Expressed in intestine; neurons; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including hereditary lymphedema; pulmonary venoocclusive disease; and thrombocytopenia. Is an ortholog of human FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
Enables peroxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; nematode larval development; and post-embryonic body morphogenesis. Predicted to be located in extracellular space. Expressed in anterior hypodermis and hypodermal cell.
Predicted to enable 7-dehydrocholesterol reductase activity. Predicted to be involved in brassinosteroid biosynthetic process and cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including Greenberg dysplasia; Pelger-Huet anomaly; and autoimmune disease (multiple). Is an ortholog of human DHCR7 (7-dehydrocholesterol reductase).
Located in plasma membrane. Expressed in body wall musculature; hypodermis; pharynx; and vulva. Is an ortholog of human MEAK7 (MTOR associated protein, eak-7 homolog).