nsy-1

Caenorhabditis elegans

Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including determination of adult lifespan; positive regulation of macromolecule biosynthetic process; and response to stress. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).

sri-56

Caenorhabditis elegans

Enriched in ADAL; ASK; and ASKL based on single-cell RNA-seq studies. Is affected by several genes including clk-1; hlh-26; and ilc-17.1 based on microarray and RNA-seq studies.

rmd-5

Caenorhabditis elegans

Enriched in ASJR; ASK; ASKL; OLQ; and neurons based on single-cell RNA-seq and microarray studies. Is affected by several genes including etr-1; pqm-1; and spn-4 based on RNA-seq and microarray studies. Is affected by multi-walled carbon nanotube; metformin; and cadmium based on RNA-seq studies.

F02D8.1

Caenorhabditis elegans

Enriched in ADF; ADFL; ASK; ASKL; and neurons based on single-cell RNA-seq; RNA-seq; and microarray studies. Is affected by several genes including qui-1; mter-4; and csr-1 based on microarray and RNA-seq studies. Is affected by six chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.

srg-2

Caenorhabditis elegans

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in membrane.

sra-7

Caenorhabditis elegans

Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Expressed in head and tail.

B0228.9

Caenorhabditis elegans

Enriched in several structures, including ASK; CEPsoDL; arcade cell; excretory secretory system; and pharyngeal cell based on single-cell RNA-seq and RNA-seq studies. Is affected by several genes including prg-1; drh-3; and rpn-10 based on tiling array; microarray; and RNA-seq studies. Is predicted to encode a protein with the following domains: DUF5382, N-terminal domain; DUF5382, C-terminal domain; DUF5382, central domain; Family of unknown function (DUF5382) C-terminal domain; Family of unknown function (DUF5382) N-terminal domain; and Family of unknown function (DUF5382) central domain.

srbc-64

Caenorhabditis elegans

Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and dauer larval development. Located in non-motile cilium and periciliary membrane compartment. Expressed in ASKL and ASKR.

srbc-66

Caenorhabditis elegans

Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and dauer larval development. Located in non-motile cilium and periciliary membrane compartment. Expressed in ASKL and ASKR.

dac-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in thermotaxis. Located in nucleus. Expressed in amphid neurons; cuticular ala; and tail. Is an ortholog of human DACH1 (dachshund family transcription factor 1).