ahr-1

Caenorhabditis elegans

Enables DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of locomotion and response to xenobiotic stimulus. Predicted to be located in nucleus. Predicted to be part of nuclear aryl hydrocarbon receptor complex. Expressed in ALML; ALMR; RMEL; RMER; and neurons. Human ortholog(s) of this gene implicated in pancreatic cancer and retinitis pigmentosa 85. Is an ortholog of human AHR (aryl hydrocarbon receptor).

aipr-1

Caenorhabditis elegans

Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Expressed in several structures, including amphid sheath cell; dorsal nerve cord; neurons; oocyte; and spermatheca. Human ortholog(s) of this gene implicated in eye disease (multiple) and pituitary adenoma 1. Is an ortholog of human AIP (aryl hydrocarbon receptor interacting protein).

aha-1

Caenorhabditis elegans

Enables DNA binding activity; DNA-binding transcription factor activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of transcription by RNA polymerase II; and social behavior. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in hypodermis; intestine; neurons; and pharynx. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in renal cell carcinoma and type 2 diabetes mellitus. Is an ortholog of human ARNT (aryl hydrocarbon receptor nuclear translocator) and ARNT2 (aryl hydrocarbon receptor nuclear translocator 2).

agt-1

Caenorhabditis elegans

Enables damaged DNA binding activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in DNA alkylation repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); and high grade glioma (multiple). Is an ortholog of human MGMT (O-6-methylguanine-DNA methyltransferase).

T01G1.4

Caenorhabditis elegans

Predicted to enable transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Predicted to be involved in polyprenol biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Is an ortholog of human DHDDS (dehydrodolichyl diphosphate synthase subunit).

F37B12.3

Caenorhabditis elegans

Predicted to enable transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Predicted to be involved in dolichol biosynthetic process and protein glycosylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Is an ortholog of human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit).

ssu-1

Caenorhabditis elegans

Enables aryl sulfotransferase activity. Involved in sulfur compound metabolic process. Located in cytosol. Expressed in ASJL and ASJR. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); lung non-small cell carcinoma (multiple); and reproductive organ cancer (multiple). Is an ortholog of several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1E1 (sulfotransferase family 1E member 1).