Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Located in cell leading edge and cytoplasm. Expressed in hypodermis. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); glioblastoma; and opisthorchiasis. Is an ortholog of human ACTR3 (actin related protein 3).
Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Predicted to be located in cell cortex. Predicted to be part of Arp2/3 protein complex. Expressed in Q cell; anchor cell; apoptotic cell; seam cell; and socket cell. Human ortholog(s) of this gene implicated in colorectal carcinoma and lung disease. Is an ortholog of human ACTR2 (actin related protein 2).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).