arl-13

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in cilium organization; receptor localization to non-motile cilium; and sensory perception of chemical stimulus. Acts upstream of or within motile cilium assembly. Located in plasma membrane bounded cell projection. Expressed in ciliated neurons and head. Used to study Joubert syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Is an ortholog of human ARL13B (ADP ribosylation factor like GTPase 13B).

arl-8

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in axo-dendritic transport; endosome to lysosome transport; and regulation of anterograde synaptic vesicle transport. Located in lysosome; presynaptic active zone; and synaptic vesicle. Expressed in coelomocyte and muscle cell. Is an ortholog of human ARL8A (ADP ribosylation factor like GTPase 8A).

arl-3

Caenorhabditis elegans

Predicted to enable GTP binding activity. Predicted to be involved in cilium assembly. Predicted to be located in cytoplasm and microtubule cytoskeleton. Expressed in head neurons and tail neurons. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Is an ortholog of human ARL3 (ADP ribosylation factor like GTPase 3).

arl-6

Caenorhabditis elegans

Enables GTPase activity. Involved in intracellular transport. Located in axoneme; cytosol; and dendrite. Expressed in ciliated neurons. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Is an ortholog of human ARL6 (ADP ribosylation factor like GTPase 6).

aptf-4

Caenorhabditis elegans

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of cell population proliferation. Predicted to be located in nucleus. Expressed in head neurons and ventral nerve cord.

mel-4

Caenorhabditis elegans

Acts upstream of or within embryo development.

arl-5

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in microtubule cytoskeleton organization. Predicted to be located in trans-Golgi network. Is an ortholog of human ARL5A (ADP ribosylation factor like GTPase 5A) and ARL5B (ADP ribosylation factor like GTPase 5B).

fkh-4

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus.

inpp-4B

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be involved in phosphatidylinositol-3-phosphate biosynthetic process. Predicted to be located in cytoplasm. Is an ortholog of human INPP4B (inositol polyphosphate-4-phosphatase type II B).

W02D3.12

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex II assembly. Predicted to be located in mitochondrion. Is an ortholog of human SDHAF4 (succinate dehydrogenase complex assembly factor 4).