arf-5

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in embryo development and germ cell development. Predicted to be located in plasma membrane. Expressed in several structures, including body wall musculature; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF5 (ADP ribosylation factor 5).

Y106G6G.2

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Is an ortholog of human ARFGEF3 (ARFGEF family member 3).

agef-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in protein transport and regulation of ARF protein signal transduction. Expressed in coelomocyte; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2).

arl-3

Caenorhabditis elegans

Predicted to enable GTP binding activity. Predicted to be involved in cilium assembly. Predicted to be located in cytoplasm and microtubule cytoskeleton. Expressed in head neurons and tail neurons. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Is an ortholog of human ARL3 (ADP ribosylation factor like GTPase 3).

arf-6

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF6 (ADP ribosylation factor 6).

grp-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Located in midbody and nucleus. Expressed in somatic cell. Is an ortholog of human CYTH4 (cytohesin 4).

apt-9

Caenorhabditis elegans

Predicted to enable small GTPase binding activity. Involved in protein secretion. Predicted to be located in trans-Golgi network. Is an ortholog of human GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1).

arf-1

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including oocyte development; regulation of apoptotic process involved in development; and regulation of receptor-mediated endocytosis. Located in endoplasmic reticulum. Expressed in pharyngeal muscle cell; uterus; ventral nerve cord; and vulval precursor cell. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARF1 (ADP ribosylation factor 1) and ARF3 (ADP ribosylation factor 3).

arc-1

Caenorhabditis elegans

Predicted to enable GTPase activity; small molecule binding activity; and transferase activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in lysosomal membrane and plasma membrane. Is an ortholog of human TRIM23 (tripartite motif containing 23).

cnt-1

Caenorhabditis elegans

Enables phosphatidylinositol phosphate binding activity and small GTPase binding activity. Involved in apoptotic process; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and endosome membrane. Used to study cancer. Is an ortholog of human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1); ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2); and ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3).