Predicted to enable GTP binding activity and GTPase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in plasma membrane.
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in protein transport and regulation of ARF protein signal transduction. Expressed in coelomocyte; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2).
Predicted to enable ribonucleoprotein complex binding activity. Involved in triglyceride metabolic process. Located in nuclear body. Expressed in gonad. Used to study Renpenning syndrome. Human ortholog(s) of this gene implicated in Renpenning syndrome. Is an ortholog of human PQBP1 (polyglutamine binding protein 1).
Predicted to enable ATP:ADP antiporter activity. Involved in determination of adult lifespan; mitochondrion organization; and positive regulation of apoptotic process. Located in mitochondrion. Expressed in several structures, including body wall musculature; hermaphrodite somatic gonadal cell; intestine; pharynx; and vulva. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2; facioscapulohumeral muscular dystrophy; intrinsic cardiomyopathy (multiple); and mitochondrial DNA depletion syndrome (multiple). Is an ortholog of human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6).
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Is an ortholog of human ARFGEF3 (ARFGEF family member 3).
Predicted to enable glyoxalase III activity. Involved in several processes, including cellular aldehyde metabolic process; cellular response to aldehyde; and monocarboxylic acid biosynthetic process. Located in cytoplasm and nucleus. Expressed in intestine. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease 7; Parkinsonism; and middle cerebral artery infarction. Is an ortholog of human PARK7 (Parkinsonism associated deglycase).
Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF6 (ADP ribosylation factor 6).