let-107

Caenorhabditis elegans

nhr-107

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Y66D12A.8

Caenorhabditis elegans

Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 107. Is an ortholog of human STEEP1 (STING1 ER exit protein 1).

C18B2.4

Caenorhabditis elegans

Predicted to enable chromatin DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Is an ortholog of human WBP2 (WW domain binding protein 2).

wbp-2

Caenorhabditis elegans

Predicted to enable chromatin DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Is an ortholog of human WBP2 (WW domain binding protein 2).

npp-5

Caenorhabditis elegans

Predicted to be a structural constituent of nuclear pore. Involved in several processes, including kinetochore assembly; protein localization to kinetochore; and regulation of nucleus size. Located in nuclear membrane. Part of nuclear pore. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome; nephrotic syndrome type 11; and ovarian dysgenesis 6. Is an ortholog of human NUP107 (nucleoporin 107).

snap-1

Caenorhabditis elegans

Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be part of SNARE complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; Down syndrome; and developmental and epileptic encephalopathy 107. Is an ortholog of human NAPA (NSF attachment protein alpha) and NAPB (NSF attachment protein beta).

unc-85

Caenorhabditis elegans

Predicted to enable histone binding activity. Involved in egg-laying behavior and post-embryonic development. Located in nucleus. Expressed in several structures, including germ line. Is an ortholog of human ASF1A (anti-silencing function 1A histone chaperone).

asfl-1

Caenorhabditis elegans

Predicted to enable histone binding activity. Involved in DNA replication; gamete generation; and regulation of brood size. Predicted to be located in nucleus. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human ASF1A (anti-silencing function 1A histone chaperone).

dpyd-1

Caenorhabditis elegans

Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase).